SCAR PREVENTION AND POST OPERATIVE TREATMENT - JEL3108
The key driver for scar treatment demand globally is the need to improve aesthetic appeal in individuals and complete skin rejuvenation. An increase in the number of hypertrophic burn marks, which can cause pain and distort a patient’s appearance, is also helping boost the demand for scar prevention treatments.
In 2019, 234 million operations were performed world-wide. Each one of these has led to the formation of a scar. In 2020, 263,643 scar revision procedures were performed, making it one of the top five reconstruction procedures. In addition to skin corrective surgeries, scar treatment products are also widely adopted.
Patients who undergo surgeries following road accidents often develop surgical scars and are provided topical products to improve their appearance. The demand for topical products for scar treatment is therefore expected to grow rapidly. With the development of a novel treatment, used at the completion of the operation and the early post-operative days, that could reduce or prevent the formation of a scar.
Carocell Bio is developing a novel approach by preventing the formation of a scar as the primary indication. Data emerging from Carocell Bio’s initial study to reduce the inflammation occurring after a burn indicate the potential for this technology to reduce inflammation in a postoperative incision, and hence excessive collagen deposition that could lead to visible scarring.
How Surgical Incisions Heal
Normal surgical incision healing will proceed through several phases.
- The first phase involves the management of bleeding and begins in the operating room. Platelets in the blood cluster together making a sort of plug, while proteins such as collagen and fibrin work together to firmly hold it in place to stop the bleeding. Introduction of Carocell Bio’s novel peptide inhibitor of inflammation at this stage should modulate the collagen and fibrin while not increasing the bleeding.
- During the next phase, which can take up to 6 days after surgery, you may notice some pain, swelling, and slight redness (inflammation). This is a normal response of the body to an injury. During this phase, the body focuses on destroying bacteria and removing debris with the influx of oxygen, nutrients, and white blood cells. The white blood cells help to keep the wound clean and protect the wound by fighting off bacteria that may try to invade it. Early collagen deposition at this stage will later lead to scar formation. Modulating inflammatory response (without stopping it completely) using JEL3108 spray will reduce the collagen deposition during this phase which will be key to reducing/preventing the formation of a post-operative scar.
- The rebuilding phase is one in which the body can start reparative activities in the damaged area. This phase lasts from about 4 days to a month after surgery. It includes the normal development of a thickening area along the incisional line indicating deposition of new collagen in the wound, often referred to as a healing ridge. This firmness will cover the entire incision line and begin to soften and flatten about 2-3 weeks following surgery. JEL3108 will already have reduced the collagen deposition and so reduction of the healing ridge will give an early sign of efficacy – preventing the formation of a scar.
- The last phase is often referred to as the remodelling phase. This phase lasts from 21 days up to 2 years. In this final and longest phase, collagen synthesis is ongoing in order to strengthen the tissue. Remodelling occurs as the wound continues to contract and fibers are being reorganised, with a reduction in capillaries and scar formation. The scar will change in colour as it matures from red to a lighter color. By this point, Carocell Bio’s JEL3108 will already have reduced the collagen deposition and so now focuses on reducing the possibility of further scarring potential.
OUR RESEARCH
Find out more about our therapeutic peptides and how they can reduce inflammation in a host of serious inflammatory diseases.
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